Betaine Hydrochloride
Betaine Hydrochloride (Betaine HCl)
Snapshot
Betaine hydrochloride is a compound that supports healthy digestion by increasing stomach acid, helping break down proteins, absorb nutrients, and reduce bloating and indigestion.
What is Betaine Hydrochloride?
Betaine hydrochloride (Betaine HCl) is a form of betaine bound with hydrochloric acid, used primarily as a digestive aid. It serves as a supplemental source of stomach acid for individuals with low gastric acid production—a condition known as hypochlorhydria. Unlike betaine anhydrous, which supports methylation and performance, betaine HCl is focused on improving digestive function.
Where It Comes From
Betaine is naturally found in foods like beets, spinach, and grains. The hydrochloride form is synthetically produced for use in supplements. It is most commonly included in digestive enzyme formulas or taken alone in capsule form.
Key Nutrients & Compounds
Betaine HCl is a compound made by combining betaine with hydrochloric acid. This acidification mimics natural stomach acid (hydrochloric acid or HCl), helping the body digest food more efficiently. It is often paired with pepsin, a digestive enzyme that works optimally in acidic environments to break down proteins into peptides.
Health Benefits
Betaine HCl supports digestion by restoring healthy stomach acidity, which enhances protein breakdown, improves nutrient absorption (especially B12, iron, and calcium), and helps prevent reflux and bloating. It also aids in preventing bacterial overgrowth in the small intestine by maintaining an acidic pH that inhibits pathogens. For people with low stomach acid, it can reduce symptoms of indigestion, gas, and food intolerance.
Recommended Dosage
Typical doses range from 350 mg to 650 mg per capsule, taken with meals—especially those containing protein. Some protocols suggest gradually increasing dosage until a warm sensation is felt in the stomach, then backing down by one capsule. Always use under the guidance of a healthcare professional.
How to Use It
Take Betaine HCl capsules with meals, particularly those high in protein. Do not take on an empty stomach. It's often combined with pepsin or other digestive enzymes for enhanced effectiveness. Avoid use with antacids, proton pump inhibitors, or acid blockers.
Who Should Use It?
Recommended for individuals with symptoms of low stomach acid, such as bloating, indigestion, or nutrient malabsorption. It is especially helpful for older adults, people with autoimmune conditions, or long-term users of antacids.
Possible Interactions or Cautions
Betaine HCl should not be used by individuals with active ulcers, gastritis, or those taking NSAIDs or acid-reducing drugs. High doses may irritate the stomach lining if used improperly. Always consult a healthcare provider before use, especially if digestive issues are present.
Final Thoughts
Betaine hydrochloride is a highly effective digestive support supplement that restores stomach acid levels and improves nutrient absorption. When used correctly, it can dramatically improve gut comfort, protein digestion, and overall digestive efficiency.
Scientific Studies
Kokkonen, J., & Similä, S. (1983). Gastric acid secretion and serum gastrin in children with recurrent abdominal pain. Archives of Disease in Childhood, 58(7), 509–512. https://doi.org/10.1136/adc.58.7.509
Wilder-Smith, C. H., et al. (1990). Gastric acidity, plasma hormones, and functional dyspepsia: The role of acid suppression. Scandinavian Journal of Gastroenterology, 25(2), 156–162. https://doi.org/10.3109/00365529008998637
Wright, J. V., & Lenard, L. (2001). Why Stomach Acid is Good for You. M. Evans and Company. (Book reference widely cited in clinical use protocols)