Glycyrrhizin Extract
Glycyrrhizin Extract
Snapshot
Glycyrrhizin extract is derived from licorice root (Glycyrrhiza glabra) and standardized to glycyrrhizin, a triterpenoid saponin with anti‑inflammatory, hepatoprotective, and adrenal‑supportive properties.
What is Glycyrrhizin Extract?
Glycyrrhizin is the principal bioactive compound in licorice root, responsible for its sweet flavor and therapeutic effects. Extracts are concentrated to provide consistent glycyrrhizin content, typically 20–50% by weight.
Where It Comes From
Licorice roots are harvested after 3–4 years of growth, cleaned, and subjected to water or alcohol extraction. The crude extract is then purified and standardized to glycyrrhizin for use in supplements.
Key Nutrients & Compounds
Glycyrrhizin (glycyrrhizic acid) is a saponin glycoside that metabolizes to glycyrrhetinic acid in the gut. The extract also contains flavonoids (liquiritin, isoliquiritin) and other saponins contributing to its pharmacological profile.
Health Benefits
Glycyrrhizin exhibits anti‑inflammatory and antioxidant actions, helping protect liver cells and modulate immune responses. It supports adrenal health by inhibiting cortisol breakdown, thus enhancing stress resilience. Licorice extract also soothes gastrointestinal mucosa, making it useful for mild dyspepsia.
Recommended Dosage
Standardized glycyrrhizin extracts are typically dosed at 100–200 mg of glycyrrhizin per day, often split into two doses. Prolonged use should be limited to 4–6 weeks to minimize risk of mineralocorticoid effects.
How to Use It
Take glycyrrhizin extract capsules or tablets with water, preferably after meals. Deglycyrrhizinated licorice (DGL) is available for GI support and may be chewed as lozenges before eating.
Who Should Use It?
Suitable for individuals seeking liver support, stress resilience, or relief from occasional gastric discomfort. DGL forms are ideal for those needing mucosal protection without impacting cortisol metabolism.
Possible Interactions or Cautions
Excessive glycyrrhizin intake can lead to pseudo‑aldosteronism: hypertension, edema, and potassium depletion. Avoid in individuals with hypertension, heart disease, or kidney dysfunction. Do not use during pregnancy or with corticosteroids without medical supervision.
Final Thoughts
Glycyrrhizin extract delivers potent licorice root benefits—anti‑inflammatory, hepatoprotective, and adrenal‑supportive—when used thoughtfully. Short‑term, standardized use can enhance stress coping and digestive health.
Scientific Studies
Fiore, C., Eisenhut, M., Krausse, R., et al. (2008). Antiviral effects of Glycyrrhiza species. Phytotherapy Research, 22(2), 141–148.
https://doi.org/10.1002/ptr.2297
Wang, Z. Y., & Nixon, D. W. (2001). Licorice and cancer. Nutrition and Cancer, 39(1), 1–11.
https://doi.org/10.1207/S15327914NC391_1
Armanini, D., et al. (2003). Treatment of menopausal hot flushes with a combination of Pueraria mirifica and licorice. Maturitas, 44(3), 243–247.
https://doi.org/10.1016/S0378-5122(02)00300-5