Grape Seed Extract
Snapshot
Grape seed extract is a concentrated source of oligomeric proanthocyanidins (OPCs), potent antioxidants that support cardiovascular health, skin integrity, and microcirculation.
What is Grape Seed Extract?
Grape seed extract is derived from the seeds of grapes (Vitis vinifera) and standardized to high levels of OPCs. These flavonoid compounds deliver antioxidant capacity far exceeding that of vitamin C or E.
Where It Comes From
After winemaking, grape seeds are collected, dried, and processed via solvent extraction (often ethanol or water) to isolate and concentrate OPCs into powders or capsules.
Key Nutrients & Compounds
The primary actives are oligomeric proanthocyanidins (dimers to tetramers of catechins), along with monomeric flavan-3-ols (catechin, epicatechin). These compounds neutralize free radicals, support collagen stability, and enhance blood vessel integrity.
Health Benefits
Grape seed OPCs improve endothelial function, lower LDL oxidation, and support healthy blood pressure. Their antioxidant action protects skin from UV damage and aging. OPCs also aid microcirculation, reducing edema and promoting vascular health.
Recommended Dosage
Typical dosages range from 100 to 300 mg of extract standardized to 90% OPCs per day, often divided into two doses. For specific circulatory support, higher-end dosing under professional guidance may be used.
How to Use It
Take grape seed extract capsules or tablets with meals to enhance absorption. Powder forms can be mixed into smoothies or beverages.
Who Should Use It?
Ideal for individuals seeking antioxidant support, cardiovascular protection, or skin health maintenance. It benefits those with poor microcirculation, borderline blood pressure, or UV exposure concerns.
Possible Interactions or Cautions
Grape seed extract may potentiate blood-thinning medications; monitor bleeding risk if combined. Mild headache or dizziness can occur. Avoid in pregnancy or if on hormone-sensitive therapies without medical advice.
Final Thoughts
Grape seed extract delivers a powerful, natural antioxidant complex that supports vascular integrity, skin resilience, and overall oxidative balance, making it a valuable addition to wellness protocols.
Scientific Studies
Sano, A., et al. (2007). Effects of proanthocyanidin-rich grape seed extract on blood pressure and vascular function in prehypertensive humans: a randomized, double‑blind, placebo‑controlled study. Journal of Hypertension, 25(6), 1385–1392.
https://doi.org/10.1097/HJH.0b013e3280be6fcb
Luo, J., et al. (2008). Grape seed proanthocyanidin extract ameliorates UV‑induced skin damage in hairless mice. Photochemical & Photobiological Sciences, 7(4), 468–474.
https://doi.org/10.1039/B717105C
Steinberg, F. M., et al. (2003). Grape seed proanthocyanidins are more effective antioxidants than vitamins C and E in human plasma. Journal of Agricultural and Food Chemistry, 51(9), 2719–2723.
https://doi.org/10.1021/jf020763h