Graviola
Graviola
Snapshot
Graviola, also known as soursop (Annona muricata), is a tropical fruit extract valued for its antioxidant, antimicrobial, and potential anticancer properties.
What is Graviola?
Graviola is derived from the leaves, fruit, and bark of the soursop tree. Extracts concentrate annonaceous acetogenins and polyphenols, which are credited with many of the plant’s bioactive effects.
Where It Comes From
Native to Central and South America and cultivated across the tropics, graviola parts are harvested, shade‑dried, and processed via alcohol or water extraction into powders, capsules, or tinctures.
Key Nutrients & Compounds
Graviola extract contains annonaceous acetogenins (e.g., annonacin), alkaloids, flavonoids, and phenolic acids. Acetogenins are lipophilic compounds that may modulate mitochondrial function and exhibit cytotoxic activity against certain cell lines.
Health Benefits
Graviola exhibits potent antioxidant and anti‑inflammatory effects, supporting cellular health. In vitro studies suggest acetogenins may inhibit growth of various cancer cell lines. Graviola also demonstrates antimicrobial activity against bacteria and parasites, and may support healthy immune responses.
Recommended Dosage
Standardized graviola extracts (4–8% acetogenins) are typically dosed at 500–1,000 mg per day, taken in divided doses with meals. Duration should be limited to 6–8 weeks pending further safety data.
How to Use It
Take graviola capsules or tablets with water. Tinctures can be dosed at 1–2 mL, two to three times daily, mixed in juice or water.
Who Should Use It?
Suitable for individuals seeking antioxidant support or exploring complementary botanical options. Those considering graviola for its potential anticancer properties should do so under medical guidance.
Possible Interactions or Cautions
High intake of annonacin may be neurotoxic over prolonged periods; avoid excessive or long‑term use. Graviola may interact with chemotherapy agents and should not replace conventional cancer treatments. Consult a healthcare provider before use if pregnant, nursing, or on medications.
Final Thoughts
Graviola offers a rich profile of bioactive acetogenins and phenolics with promising in vitro activity. While its traditional use and preliminary research are encouraging, more clinical studies are needed to confirm efficacy and safety in humans.
Scientific Studies
Rivière, C., et al. (2012). Anticancer properties and mechanism of action of annonaceous acetogenins. Cancer Chemotherapy and Pharmacology, 69(6), 1421–1439.
https://doi.org/10.1007/s00280-011-1786-8
dos Santos, L. A., et al. (2018). Antimicrobial and antiparasitic activities of graviola (Annona muricata) leaf extract. Journal of Ethnopharmacology, 223, 126–131.
https://doi.org/10.1016/j.jep.2018.05.001
Shu, Z., et al. (2014). Soursop leaf extract induces apoptosis and cell cycle arrest in human breast cancer cells. Journal of Ethnopharmacology, 153(3), 824–833.
https://doi.org/10.1016/j.jep.2014.03.056