Hesperidin
Hesperidin
Snapshot
Hesperidin is a flavonoid glycoside predominantly found in citrus fruits, known for its vascular‑protective, anti‑inflammatory, and antioxidant benefits.
What is Hesperidin?
Hesperidin is a bioflavonoid composed of the aglycone hesperetin bound to the sugar rutinose. It is abundant in the peel and pulp of oranges, lemons, and other citrus fruits, where it contributes to health‑promoting effects.
Where It Comes From
Commercial hesperidin is extracted from citrus peels—particularly from sweet orange (Citrus sinensis) by‑products—using solvent or enzyme‑assisted processes to concentrate and purify the flavonoid.
Key Nutrients & Compounds
Hesperidin itself is the key compound, often expressed as ≥90% purity in extracts. It may be accompanied by other citrus flavonoids such as narirutin and eriocitrin, which enhance its antioxidant and anti‑inflammatory actions.
Health Benefits
Hesperidin supports healthy capillary strength and microcirculation, reduces markers of inflammation, and protects endothelial cells from oxidative damage. It may help maintain healthy blood pressure and lipid profiles and supports skin health by improving collagen stability.
Recommended Dosage
Typical doses range from 500 mg to 1,000 mg of hesperidin extract per day, often divided into two doses. Some protocols use up to 2,000 mg daily for enhanced vascular support under professional guidance.
How to Use It
Take hesperidin capsules or tablets with water, preferably with meals to improve absorption. Powdered extracts can be mixed into beverages or smoothies.
Who Should Use It?
Ideal for individuals seeking natural support for vascular health, healthy blood pressure, and antioxidant protection. It may benefit those with mild circulation issues or looking to enhance skin resilience.
Possible Interactions or Cautions
Hesperidin is generally well tolerated; high doses may cause mild gastrointestinal upset. It can potentiate the effects of anticoagulant medications—monitor clotting parameters if combined. Consult a healthcare provider if pregnant, nursing, or on prescription therapies.
Final Thoughts
Hesperidin offers targeted flavonoid support for vascular integrity, inflammation modulation, and oxidative defense. When sourced from high‑quality citrus extracts and used consistently, it can bolster cardiovascular and skin health.
Scientific Studies
Loke, W. M., Proudfoot, J. M., & Hodgson, J. M. (2010). Pure dietary flavonoids quercetin and hesperetin augment nitric oxide products and endothelium‑dependent vasodilation in healthy men. Journal of Clinical Endocrinology & Metabolism, 95(10), 4819–4825.
https://doi.org/10.1210/jc.2010-0232
Morand, C., et al. (2011). Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. American Journal of Clinical Nutrition, 93(1), 73–80.
https://doi.org/10.3945/ajcn.110.004073
Nishiumi, S., et al. (2011). Hesperidin exhibits anti‑cancer effects through epigenetic modulation of human cancer cell lines. Journal of Nutritional Biochemistry, 22(9), 796–803.
https://doi.org/10.1016/j.jnutbio.2010.07.010