Inositol
Inositol
Snapshot
Inositol is a cyclitol (sugar alcohol) involved in cellular signaling, nerve function, and lipid metabolism, supporting mood balance, reproductive health, and metabolic regulation.
What is Inositol?
Inositol refers to a family of six stereoisomers, with myo‑inositol being the most biologically active form. It plays a key role as a second messenger in insulin and neurotransmitter pathways, including serotonin signaling.
Where It Comes From
Myo‑inositol is synthesized endogenously from glucose‑6‑phosphate in the body. Dietary sources include fruits (especially cantaloupe and citrus), beans, nuts, grains, and meat. Supplements provide purified myo‑inositol, often combined with D‑chiro‑inositol.
Key Nutrients & Compounds
Myo‑inositol itself is the active compound; some formulations include D‑chiro‑inositol or a specific 40:1 myo‑ to D‑chiro‑inositol ratio to mimic physiological balance and enhance reproductive and metabolic effects.
Health Benefits
Inositol supports insulin sensitivity and healthy blood sugar regulation, making it beneficial for metabolic syndrome and polycystic ovary syndrome (PCOS). It modulates neurotransmitter activity, promoting mood stability and reducing symptoms of anxiety and depression. Inositol also aids nerve conduction and may improve lipid profiles.
Recommended Dosage
Typical doses range from 2 to 12 grams of myo‑inositol per day, often split into two doses. For PCOS, 2 g myo‑inositol plus 50 mg D‑chiro‑inositol twice daily is common. Start at lower doses and titrate based on tolerance.
How to Use It
Mix inositol powder into water or juice and drink on an empty stomach or with meals. Capsules are also available; higher doses may require powder form for convenience.
Who Should Use It?
Ideal for individuals with insulin resistance, PCOS, or mood disorders such as anxiety and depression. It may also benefit those seeking cognitive support, healthy lipid metabolism, or improved nerve function.
Possible Interactions or Cautions
Inositol is generally well tolerated; high doses can cause mild gastrointestinal discomfort (bloating, diarrhea). It may lower blood sugar—monitor levels if on antidiabetic medications. Consult a healthcare provider if pregnant or nursing.
Final Thoughts
Inositol offers versatile support across metabolic, reproductive, and neurological domains. Its safety profile and multifaceted benefits make it a valuable supplement for enhancing insulin sensitivity, mood balance, and cellular signaling health.
Scientific Studies
Gerli, S., et al. (2003). Myo‑inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecological Endocrinology, 17(5), 341–349.
https://doi.org/10.1080/0951359031000156274
Raffone, E., et al. (2010). Effect of myo‑inositol and D‑chiro‑inositol in type 2 diabetes: a systematic review and meta‑analysis. European Review for Medical and Pharmacological Sciences, 14(12), 1073–1080.
https://pubmed.ncbi.nlm.nih.gov/21197903/
Larner, J. (2002). D‑chiro‑inositol—its functional role in insulin action and its deficit in insulin resistance. International Journal of Experimental Diabetes Research, 3(1), 47–60.
https://doi.org/10.1155/2002/989246