Japanese Knotweed Extract
Japanese Knotweed Extract (Polygonum cuspidatum)
Snapshot
Japanese knotweed extract is derived from the roots of Polygonum cuspidatum, rich in resveratrol and polyphenols that support antioxidant defenses, cardiovascular health, and healthy aging.
What is Japanese Knotweed Extract?
Japanese knotweed extract is a concentrated botanical supplement obtained from the dried roots of the invasive plant Polygonum cuspidatum. It is standardized to provide high levels of resveratrol and other stilbenes.
Where It Comes From
The robust roots of Japanese knotweed are harvested in late summer or autumn, washed, dried, and extracted—commonly via ethanol or water—then purified and standardized (often to 50–98% resveratrol) for supplement use.
Key Nutrients & Compounds
The principal active is resveratrol, a stilbene polyphenol. Other constituents include piceid (resveratrol glucoside), emodin, and various flavonoids and tannins, all contributing to the extract’s bioactivity.
Health Benefits
Resveratrol and related polyphenols support cardiovascular function by promoting healthy endothelial flexibility, reducing oxidative stress, and modulating inflammatory pathways. They also activate cellular longevity pathways (sirtuins) and protect against age‑related cellular damage.
Recommended Dosage
Typical doses range from 100 to 500 mg of extract (providing 50–250 mg resveratrol) per day, often taken in divided doses with meals to enhance absorption and reduce gastrointestinal discomfort.
How to Use It
Take Japanese knotweed extract capsules or tablets with water, ideally with food. Some formulations combine it with other antioxidants (e.g., quercetin) or piperine to improve bioavailability.
Who Should Use It?
Ideal for adults seeking antioxidant support, cardiovascular health maintenance, or cellular longevity aid. It may benefit those interested in healthy aging or mitigating oxidative stress.
Possible Interactions or Cautions
High doses of resveratrol can interact with blood thinners and antiplatelet drugs. It may also affect estrogen‑sensitive conditions. Mild gastrointestinal upset can occur. Consult a healthcare provider if you have a bleeding disorder or are on prescription medications.
Final Thoughts
Japanese knotweed extract is a concentrated source of resveratrol and related polyphenols, offering potent antioxidant and cardio‑protective benefits. When standardized and used responsibly, it supports vascular health and healthy aging.
Scientific Studies
Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews Drug Discovery, 5(6), 493–506.
https://doi.org/10.1038/nrd2060
Bhatt, J. K., et al. (2012). Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutrition Research, 32(7), 537–541.
https://doi.org/10.1016/j.nutres.2012.06.004
Fouda, A. S., et al. (2016). Pharmacokinetics and tissue distribution of resveratrol and its metabolites in rat after oral administration of Japanese knotweed extract. Drug Metabolism and Disposition, 44(9), 1312–1322.
https://doi.org/10.1124/dmd.116.070244