L-Glutathione
L‑Glutathione
Snapshot
L‑Glutathione is a tripeptide antioxidant composed of glutamate, cysteine, and glycine, essential for cellular redox balance, detoxification, and immune support.
What is L‑Glutathione?
L‑Glutathione (GSH) is the body’s primary endogenous antioxidant, synthesized intracellularly. It detoxifies reactive oxygen species, regenerates other antioxidants (vitamin C and E), and participates in enzyme‑mediated conjugation of toxins.
Where It Comes From
Cells produce glutathione via the γ‑glutamyl cycle, combining glutamate, cysteine, and glycine. Oral supplements use reduced glutathione or precursors like N‑acetylcysteine to boost intracellular levels.
Key Nutrients & Compounds
Supplemental forms include reduced glutathione (GSH) and liposomal or acetylated formulations to enhance bioavailability. Precursor supplements (N‑acetylcysteine, whey protein) support endogenous synthesis.
Health Benefits
Glutathione neutralizes free radicals, supports liver detoxification through glutathione‑S‑transferase pathways, and maintains immune cell function. It also protects mitochondria from oxidative damage and supports cellular repair mechanisms.
Recommended Dosage
Typical oral doses range from 250 to 500 mg of reduced glutathione per day. Precursor dosing (e.g., 600 mg N‑acetylcysteine) may more effectively raise intracellular GSH. Liposomal forms may allow lower doses with improved uptake.
How to Use It
Take glutathione on an empty stomach to enhance absorption. Liposomal and sublingual forms further improve bioavailability. Combining with vitamin C and selenium supports recycling of oxidized glutathione.
Who Should Use It?
Ideal for individuals under oxidative stress—such as those exposed to pollution, heavy exercise, or aging—who seek enhanced antioxidant protection, liver support, and immune resilience.
Possible Interactions or Cautions
Generally safe; high doses may cause gastrointestinal discomfort or allergic reactions in sensitive individuals. Those with active cancer should consult an oncologist, as glutathione can influence chemotherapy efficacy.
Final Thoughts
L‑Glutathione is a cornerstone antioxidant and detoxifier. When supplemented appropriately—especially in bioavailable forms—it bolsters cellular defenses, supports detox pathways, and enhances overall health.
Scientific Studies
Pizzorno, J. (2014). Glutathione! Integrative Medicine (Encinitas), 13(1), 8–12.
https://pubmed.ncbi.nlm.nih.gov/24554945/
Allen, J., Bradley, R. D. (2011). Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. Journal of Alternative and Complementary Medicine, 17(9), 827–833.
https://doi.org/10.1089/acm.2010.0307
Richie, J. P., et al. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition, 54(2), 251–263.
https://doi.org/10.1007/s00394-014-0769-9