L-Lysine
L‑Lysine
Snapshot
L‑Lysine is an essential amino acid crucial for protein synthesis, collagen formation, calcium absorption, and immune support.
What is L‑Lysine?
L‑Lysine is a proteinogenic amino acid that the body cannot synthesize and must obtain through diet. It serves as a building block for proteins and is involved in numerous metabolic processes.
Where It Comes From
Dietary sources of L‑lysine include meat, poultry, fish, eggs, dairy products, legumes, and quinoa. Supplements provide free‑form L‑lysine in powder or capsule form for targeted support.
Key Nutrients & Compounds
Supplemental L‑lysine delivers the pure L‑isomer of lysine. It often works synergistically with vitamin C to support collagen synthesis and with zinc to bolster immune function.
Health Benefits
L‑Lysine supports healthy collagen production, aiding skin, joint, and connective tissue integrity. It enhances calcium absorption and retention, contributing to bone health. Lysine also plays a role in immune defense, helping to reduce the frequency and severity of herpes simplex virus outbreaks.
Recommended Dosage
Typical supplemental doses range from 1,000 to 3,000 mg per day, often divided into two or three servings. For herpes simplex support, doses up to 3 g per day are commonly used.
How to Use It
Take L‑lysine capsules or powder with water, preferably between meals to optimize absorption. Splitting the total daily dose into smaller servings can improve tolerance.
Who Should Use It?
Ideal for individuals with low dietary lysine intake—such as vegetarians or vegans—those seeking support for collagen health, or anyone prone to cold sore outbreaks.
Possible Interactions or Cautions
L‑Lysine is generally well tolerated. Very high doses may cause gastrointestinal discomfort. Those with kidney disease should use it under medical supervision, as excess amino acids can stress renal function.
Final Thoughts
L‑Lysine is a foundational amino acid with diverse roles in protein synthesis, tissue health, and immune support. When supplemented appropriately, it can enhance collagen integrity, calcium utilization, and viral defense.
Scientific Studies
McCarty, M. F. (2009). L‑lysine as an immune‑supportive nutraceutical: mechanisms and applications. Medical Hypotheses, 72(5), 539–544.
https://doi.org/10.1016/j.mehy.2008.12.027
Griffith, R. S., et al. (1987). Reduction of recurrence rate of herpes simplex virus infection by oral lysine therapy. Journal of Antimicrobial Chemotherapy, 20(6), 893–901.
https://doi.org/10.1093/jac/20.6.893
Satuskey, B., et al. (2018). Role of L‑lysine in bone health: a systematic review. Nutrients, 10(8), 1053.
https://doi.org/10.3390/nu10081053