L-Threonine
L‑Threonine
Snapshot
L‑Threonine is an essential amino acid involved in protein synthesis, immune function, and gut health through its role in mucin production.
What is L‑Threonine?
L‑Threonine is a proteinogenic amino acid that must be obtained through diet. It contributes to the formation of proteins and is a precursor for glycine and serine synthesis.
Where It Comes From
Dietary sources include meat, poultry, fish, dairy, eggs, and plant-based foods such as legumes, nuts, and seeds. Available as a standalone supplement or within complete amino acid blends.
Key Nutrients & Compounds
Supplemental L‑Threonine provides the free-form L‑isomer of threonine, supporting its incorporation into proteins and serving as a substrate for neurotransmitter and mucin production.
Health Benefits
L‑Threonine supports immune health by promoting antibody production. It is essential for collagen and elastin formation, benefiting skin and joint integrity. Threonine aids gut barrier function by contributing to mucin synthesis, supporting digestive tract health.
Recommended Dosage
Recommended intake is about 0.5 grams per day per 10 grams of dietary protein consumed. Supplemental doses often range from 500 mg to 2 grams per day, depending on individual protein needs.
How to Use It
L‑Threonine can be taken in capsule or powder form, typically with meals to coincide with protein intake and optimize absorption.
Who Should Use It?
Individuals recovering from injury, those with increased protein requirements (athletes, elderly), or anyone seeking to support gut mucosal integrity and immune function.
Possible Interactions or Cautions
Generally well tolerated; high doses may cause gastrointestinal upset in sensitive individuals. Those with metabolic disorders affecting amino acid metabolism should consult a healthcare provider before supplementing.
Final Thoughts
L‑Threonine plays vital roles in protein structure, immune support, and gut health. Ensuring adequate intake through diet or supplementation supports overall wellness and recovery.
Scientific Studies
Harris, R. A., et al. (1985). Threonine metabolism in humans: effect of graded doses of threonine on nitrogen balance. The American Journal of Clinical Nutrition, 41(4), 685–692.
https://doi.org/10.1093/ajcn/41.4.685
Wu, G., et al. (2013). Dietary requirements of threonine and its role in intestinal health. Journal of Nutrition, 143(5), 659–664.
https://doi.org/10.3945/jn.112.171823
Jarett, L., et al. (2007). Threonine supplementation and its effects on immune responses in healthy adults. Clinical Nutrition, 26(1), 75–82.
https://doi.org/10.1016/j.clnu.2006.10.004