MSM (Methylsulfonylmethane)
MSM (Methylsulfonylmethane)
Snapshot
MSM is a sulfur-containing compound used to support joint health, reduce inflammation, and promote skin and connective tissue integrity.
What is MSM?
Methylsulfonylmethane (MSM) is an organic sulfur metabolite of dimethyl sulfoxide (DMSO), naturally present in foods and the human body, and frequently used as a dietary supplement.
Where It Comes From
MSM can be obtained from small amounts in fruits, vegetables, grains, and milk, but supplemental MSM is synthesized via the oxidation of DMSO to yield a pure, crystalline powder.
Key Nutrients & Compounds
Supplemental MSM provides bioavailable sulfur that contributes to the formation of collagen, keratin, and the antioxidant glutathione, supporting connective tissues, skin, and enzymatic detox pathways.
Health Benefits
MSM supports joint comfort by reducing inflammatory mediators; aids recovery from exercise-induced muscle soreness; enhances skin health through collagen synthesis; and may improve gut lining integrity.
Recommended Dosage
Typical doses range from 1,000 mg to 3,000 mg daily, divided into two or three servings; start with a lower dose to assess tolerance and increase gradually.
How to Use It
Mix MSM powder into water, juice, or protein shakes; it has a slightly bitter taste, so many prefer capsules or flavored blends.
Who Should Use It?
Individuals experiencing joint discomfort, athletes recovering from intense training, and anyone seeking to support connective tissue health and reduce systemic inflammation.
Possible Interactions or Cautions
Generally well tolerated; high doses may cause gastrointestinal upset or headache in sensitive individuals; consult a healthcare provider if pregnant or taking other anti-inflammatory medications.
Final Thoughts
MSM provides a bioavailable source of sulfur that supports joints, skin, and antioxidant defenses, making it a versatile supplement for overall musculoskeletal wellness.
Scientific Studies
Kalman DS, et al. Effectiveness of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized, double-blind, placebo-controlled study. Osteoarthritis Cartilage. 2006;14(3):286–294. https://doi.org/10.1016/j.joca.2005.11.005
Usha PR, Naidu MU. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, MSM and their combination in osteoarthritis. Clin Drug Investig. 2004;24(6):353–363. https://doi.org/10.2165/00044011-200424060-00004
Debbi EM, et al. Efficacy of methylsulfonylmethane (MSM) supplementation on osteoarthritis symptoms: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2011;19(7):825–833. https://doi.org/10.1016/j.joca.2011.03.011