Mucuna Pruriens Extract
Mucuna Pruriens Extract
Snapshot
Mucuna pruriens Extract is a standardized source of the bioactive compound L‑DOPA, used to support neurotransmitter balance, mood, and motor function.
What is Mucuna pruriens Extract?
Mucuna pruriens, also known as velvet bean, contains high levels of L‑DOPA (levodopa), the direct precursor to dopamine, along with other phytochemicals such as serotonin, 5‑HTP, and alkaloids.
Where It Comes From
Harvested from the seeds of the tropical legume Mucuna pruriens, seeds are de‑hulled, ground, and extracted—typically in an aqueous or alcohol medium—then concentrated and standardized to 15–20% L‑DOPA.
Key Nutrients & Compounds
Provides L‑DOPA (levodopa), which crosses the blood–brain barrier to increase dopamine synthesis, plus plant‑derived antioxidants, fiber, and protein.
Health Benefits
Supports healthy dopamine levels for mood regulation, motivation, and cognitive function; may enhance motor control in Parkinson’s‑related therapies; aids stress resilience by modulating the HPA axis.
Recommended Dosage
Standardized extracts (15–20% L‑DOPA) are typically dosed at 250–500 mg, 1–3 times daily (yielding 37–100 mg L‑DOPA per dose); adjust according to clinical guidance.
How to Use It
Take capsules or powder with water on an empty stomach or 30 minutes before meals to maximize absorption; avoid combining with high‑protein meals that may compete at transporters.
Who Should Use It?
Individuals seeking mood support, enhanced motivation, or adjunctive support for dopamine‑related conditions; use under healthcare supervision when on dopaminergic medications.
Possible Interactions or Cautions
May interact with antidepressants, MAO inhibitors, and dopaminergic drugs—risk of excessive dopamine activity; may cause nausea or headaches at higher doses; consult a healthcare provider before use.
Final Thoughts
Mucuna pruriens Extract offers a natural, plant‑derived source of L‑DOPA for supporting dopamine‑mediated functions, but dosing and interactions require careful management.
Scientific Studies
Shukla R, et al. Comparative evaluation of Mucuna pruriens and levodopa/benserazide in Parkinson’s disease: a randomized trial. Phytother Res. 2009;23(9):1303–1307. https://doi.org/10.1002/ptr.2793
Katzenschlager R, et al. Mucuna pruriens in Parkinson’s disease: double-blind randomized trial. J Neurol Neurosurg Psychiatry. 2004;75(12):1672–1677. https://doi.org/10.1136/jnnp.2003.023145
Manyam BV, et al. Neuroprotective effects of Mucuna pruriens—reversal of MPTP toxicity in mice. Pharmacol Biochem Behav. 2004;78(2):419–424. https://doi.org/10.1016/j.pbb.2004.08.028