S-Allyl Cysteine
S-Allyl Cysteine
Snapshot
S‑Allyl Cysteine is a water‑soluble organosulfur compound abundant in aged garlic extract, offering antioxidant, cardioprotective, and neuroprotective benefits through modulation of oxidative stress and inflammation.
What is S‑Allyl Cysteine?
S‑Allyl Cysteine (SAC) is a stable, bioavailable sulfur‑containing amino acid derivative formed during the aging of garlic. Unlike raw garlic’s unstable compounds, SAC survives processing and digestion, making it a key active constituent of aged garlic supplements.
Where It Comes From
SAC is generated when fresh garlic cloves are sliced and macerated in ethanol or water for extended periods (weeks to months). This aging process converts harsher thiosulfinates into gentle, stable compounds. The resulting extract is filtered and concentrated into powders or capsules standardized for SAC content.
Key Nutrients & Compounds
This extract primarily provides S‑allyl cysteine alongside minor amounts of S‑allyl mercaptocysteine, flavonoids, and trace minerals, all contributing synergistically to its bioactivity.
Health Benefits
S‑Allyl Cysteine scavenges free radicals and upregulates endogenous antioxidant enzymes, protecting cells from oxidative damage. It supports cardiovascular health by improving endothelial function and reducing blood pressure. Neuroprotective effects include attenuation of neuroinflammation and promotion of neuronal survival.
Recommended Dosage
Typical supplementation involves 100–300 mg of purified SAC per day, often delivered via 600–1,200 mg of aged garlic extract standardized to 2–5% SAC. Doses may be divided between morning and evening with meals.
How to Use It
Take SAC‑standardized aged garlic extract capsules with food to enhance absorption and minimize any mild gastrointestinal discomfort. Maintain consistent daily use for at least 8–12 weeks to observe cardiovascular or antioxidant benefits.
Who Should Use It?
Individuals seeking natural antioxidant support, those with mild hypertension or cardiovascular risk factors, and anyone wanting gentle garlic benefits without odor or gastric irritation. Consult a healthcare provider when combining with prescription medications.
Possible Interactions or Cautions
Generally well tolerated. Use caution if taking anticoagulant or antiplatelet drugs due to potential additive blood‑thinning effects. Rarely, high doses may cause mild gastrointestinal upset. Discontinue and consult a healthcare professional if adverse reactions occur.
Final Thoughts
S‑Allyl Cysteine from aged garlic extract offers a potent, odor‑less source of garlic’s therapeutic properties, making it an excellent choice for long‑term cardiovascular and antioxidant support when used responsibly.
Scientific Studies
Yeh YY, Yeh GL. Hypolipidemic and antioxidant effects of aged garlic extract and its constituents, S‑allyl cysteine and S‑allyl mercaptocysteine, in cholesterol-fed rabbits. Nutrition. 2006;22(1):27–37. https://doi.org/10.1016/j.nut.2005.07.005
Lawson LD, Gardner CD. Composition, stability, and bioavailability of S‑allyl cysteine and S‑allyl mercaptocysteine from aged garlic preparations. Planta Med. 2005;71(9):747–754. https://doi.org/10.1055/s-2005-872814
Amagase H, Petesch BL, Matsuura H, et al. Intake of garlic and its bioactive components: S‑allyl cysteine and S‑allyl mercaptocysteine, and association with cardiovascular health. J Nutr. 2001;131(3S):955S–962S. https://doi.org/10.1093/jn/131.3.955S