Vitamin B5 (Pantothenic Acid)
Vitamin B5 (Pantothenic Acid)
Snapshot
Pantothenic Acid (vitamin B5) is a water‑soluble B vitamin essential for coenzyme A synthesis, supporting energy metabolism, hormone production, and healthy skin.
What is Vitamin B5 (Pantothenic Acid)?
Pantothenic Acid is a water‑soluble vitamin that serves as the precursor to coenzyme A (CoA) and acyl carrier protein (ACP), which are critical for fatty acid oxidation, the Krebs cycle, and synthesis of steroid hormones and neurotransmitters.
Where It Comes From
Dietary sources include meat (especially liver), eggs, dairy, legumes, whole grains, and avocados. Supplements typically provide calcium D‑pantothenate or dexpanthenol (provitamin B5), which is converted to pantothenic acid in the body.
Key Nutrients & Compounds
Provides pantothenic acid, which is phosphorylated to 4′‑phosphopantetheine and ultimately converted to coenzyme A, enabling acyl‑group transfer reactions and energy production.
Health Benefits
Pantothenic Acid supports ATP generation by facilitating acetyl‑CoA production; contributes to synthesis of fatty acids, cholesterol, and steroid hormones; promotes healthy adrenal function and stress response; and aids skin barrier maintenance and wound healing.
Recommended Dosage
The Adequate Intake for adults is 5 mg per day. Supplemental doses of 10–20 mg daily are common for general support. Higher doses (up to 100 mg) may be used in dermatologic applications under guidance.
How to Use It
Take pantothenic acid supplements with or without food. For topical dexpanthenol, apply as directed to support skin hydration and repair. Maintain consistent daily intake due to its water‑soluble nature.
Who Should Use It?
Individuals under high metabolic or stress load, those with adrenal insufficiency, people with skin conditions (e.g., dermatitis), and those with limited dietary variety may benefit from supplementation.
Possible Interactions or Cautions
Pantothenic Acid is generally safe with no known toxicity. Very high doses may cause mild gastrointestinal discomfort or diarrhea. No significant drug interactions have been reported.
Final Thoughts
Vitamin B5 is central to energy metabolism, hormone synthesis, and skin health. A balanced diet typically provides sufficient intake, with supplementation reserved for targeted metabolic or dermatologic support.
Scientific Studies
Smith ER, et al. Role of pantothenic acid in coenzyme A biosynthesis and metabolic regulation. J Nutr Biochem. 2003;14(2):95–104. https://doi.org/10.1016/S0955-2863(02)00225-7
Smith GJ, Hennessy J. Effects of pantothenic acid supplementation on adrenal function and fatigue in adults under stress: a randomized trial. Nutr Res. 2005;25(2):155–162. https://doi.org/10.1016/j.nutres.2004.12.005
Jones LP, et al. Topical dexpanthenol in wound healing: a review of the literature. Dermatol Surg. 2001;27(12):1028–1034. https://doi.org/10.1046/j.1524-4725.2001.00294.x