Cellulase
Cellulase
Snapshot
Cellulase is a group of digestive enzymes that break down cellulose into glucose, supporting fiber digestion, nutrient absorption, and overall gut health.
What is Cellulase?
Cellulase refers to a family of enzymes—including endoglucanases, exoglucanases, and β-glucosidases—that catalyze the hydrolysis of cellulose, the primary structural component of plant cell walls. In supplement form, cellulase aids the human digestive system by helping to break down dietary fiber that otherwise passes through largely undigested.
Where It Comes From
Cellulase is naturally produced by microorganisms such as fungi (Trichoderma reesei) and bacteria (Clostridium thermocellum), and can also be derived from certain plant sources. Commercial supplements typically use fungal or bacterial strains that have been cultured and purified to yield high enzyme activity.
Key Nutrients & Compounds
Cellulase preparations contain multiple enzyme activities—endoglucanase to cleave internal bonds in cellulose chains, exoglucanase to release cellobiose units from chain ends, and β-glucosidase to convert cellobiose into glucose. These synergistic activities enhance the breakdown of complex plant fibers into absorbable sugars.
Health Benefits
Supplemental cellulase improves the digestibility of high‑fiber foods, reducing bloating, gas, and discomfort associated with fiber fermentation. By enhancing nutrient release from plant-based meals, it supports better mineral and vitamin uptake. It may also promote a healthy gut microbiome by modulating fiber availability and reducing intestinal irritation.
Recommended Dosage
Dosages vary by enzyme activity units but typically range from 50 to 300 mg of cellulase blend per meal. Look for products standardized to specific cellulase activity (e.g., 5,000 to 50,000 CMCU) and follow label instructions for optimal results.
How to Use It
Cellulase supplements are taken with meals containing vegetables, grains, or legumes. They are often included in broad-spectrum digestive enzyme formulas alongside proteases, lipases, and amylases for comprehensive support.
Who Should Use It?
Ideal for individuals experiencing digestive discomfort after high‑fiber meals, those on plant‑based diets, or anyone seeking to maximize nutrient absorption from fibrous foods. It can also benefit older adults with reduced digestive enzyme production.
Possible Interactions or Cautions
Generally well tolerated, but high doses may cause mild gastrointestinal symptoms such as diarrhea. Those with mold allergies should choose formulations free from fungal contaminants. As with all supplements, consult a healthcare provider if pregnant, nursing, or taking medications.
Final Thoughts
Cellulase is a valuable enzyme for improving fiber digestion and nutrient uptake, making it a key addition to digestive support regimens—especially for those emphasizing plant-based nutrition.
Scientific Studies
Singhania, R. R., et al. (2013). Role and significance of cellulases in biomass deconstruction. Biotechnology Advances, 31(8), 989–1007. https://doi.org/10.1016/j.biotechadv.2013.08.004
Kuhad, R. C., et al. (2004). Enhanced cellulase production by a novel Trichoderma reesei strain. Bioresource Technology, 93(2), 179–181. https://doi.org/10.1016/j.biortech.2003.10.004
Zhang, J., et al. (2019). Effect of cellulase supplementation on gut microbiota and nutrient digestibility in animal models. Journal of the Science of Food and Agriculture, 99(4), 1595–1603. https://doi.org/10.1002/jsfa.9389