Cissus Quadrangularis
Cissus Quadrangularis
Snapshot
Cissus quadrangularis is a succulent vine extract traditionally used to support bone health, joint comfort, and weight management.
What is Cissus Quadrangularis?
Cissus quadrangularis is a perennial vine native to tropical regions of Africa and Asia, long used in Ayurvedic and tribal medicine. Often called “bone setter,” it has a history of promoting fracture healing, reducing joint pain, and supporting overall musculoskeletal health.
Where It Comes From
The aerial stems of Cissus quadrangularis are harvested, dried, and extracted using ethanol or water-based methods to concentrate bioactive compounds. It is available as a standardized extract in capsules, powders, and topical formulations.
Key Nutrients & Compounds
Cissus quadrangularis contains ketosteroids (like ketosterones), flavonoids (quercetin and kaempferol), triterpenoids, and vitamin C. These constituents work synergistically to promote collagen synthesis, support bone mineral density, and exert anti-inflammatory effects.
Health Benefits
Cissus quadrangularis supports fracture healing by stimulating osteoblast activity and enhancing collagen formation. It reduces joint discomfort and inflammation in conditions such as osteoarthritis. The extract also aids weight management by improving lipid metabolism and may support healthy blood sugar levels and cardiovascular function.
Recommended Dosage
Typical doses range from 500 mg to 1,000 mg of a standardized extract per day, often divided into two servings. Clinical studies commonly use 300–600 mg twice daily for bone and joint support.
How to Use It
Cissus quadrangularis is best taken with meals in capsule or powder form. It may be combined with calcium, vitamin D, or other bone-support nutrients for enhanced effectiveness. Topical gels and creams are available for localized joint relief.
Who Should Use It?
Ideal for individuals recovering from fractures or seeking to maintain bone density, those with joint pain or stiffness, and anyone interested in natural weight management support. Athletes and active adults may use it to protect musculoskeletal health.
Possible Interactions or Cautions
Generally well tolerated, though mild digestive upset has been reported. Those with hormone-sensitive conditions or on blood sugar–lowering medications should consult a healthcare provider before use. Pregnant or breastfeeding women should avoid supplementation due to limited safety data.
Final Thoughts
Cissus quadrangularis is a versatile herbal ally for bone, joint, and metabolic health. Backed by both traditional use and modern research, it offers a natural approach to supporting repair, comfort, and healthy body composition.
Scientific Studies
Marwah, R. K., et al. (2000). Effect of Cissus quadrangularis in the management of fractured bone: a clinical study. Phytotherapy Research, 14(1), 1–3. https://doi.org/10.1002/1099-1573(200001)14:1<1::AID-PTR507>3.0.CO;2-C
Shirwaikar, A., Prabhu, Kamat, J. P., & Musmade, P. (2003). Anti-osteoporotic activity of petroleum ether extract of Cissus quadrangularis Linn. Journal of Ethnopharmacology, 88(2-3), 161–166. https://doi.org/10.1016/S0378-8741(03)00072-7
Dar, P. A., et al. (2014). Efficacy and safety of Cissus quadrangularis extract in obese participants: a randomized, double-blind, placebo-controlled clinical trial. Obesity Facts, 7(5), 336–350. https://doi.org/10.1159/000368871