DMAE Bitartrate (Dimethylaminoethanol Bitartrate)
DMAE Bitartrate (Dimethylaminoethanol Bitartrate)
Snapshot
DMAE bitartrate is a choline precursor and cognitive support compound that may enhance mood, focus, and skin firmness.
What is DMAE Bitartrate (Dimethylaminoethanol Bitartrate)?
DMAE (dimethylaminoethanol) bitartrate is a salt form of DMAE, an organic compound structurally similar to choline. It crosses the blood–brain barrier to support acetylcholine synthesis—a key neurotransmitter for memory, attention, and mood regulation.
Where It Comes From
DMAE occurs in small amounts in fish such as anchovies and sardines. The bitartrate form is synthesized for supplements to improve stability and absorption, typically available as a fine powder or capsule.
Key Nutrients & Compounds
DMAE bitartrate supplies DMAE, which the body can convert to acetylcholine, supporting neuronal communication. It does not itself provide choline but raises acetylcholine levels in the brain. No additional nutrients are inherent in the pure bitartrate salt.
Health Benefits
DMAE bitartrate may boost mood and mental clarity by enhancing acetylcholine availability, improving focus, and reducing mental fatigue. Some users report improved skin tone and firmness when applied topically, attributed to DMAE’s potential to tighten cell membranes.
Recommended Dosage
Typical doses range from 100 mg to 300 mg per day, taken in divided servings. Start at the lower end to assess tolerance and avoid overstimulation.
How to Use It
Oral DMAE bitartrate is taken with water, ideally in the morning or before mentally demanding tasks. It can be combined with other nootropics like choline sources (alpha-GPC) for synergistic cognitive support. Topical formulations are applied to clean skin before moisturizing.
Who Should Use It?
Suitable for individuals seeking enhanced cognitive function, mood support, or skin-firming effects. It’s commonly used by students, professionals, and anyone experiencing brain fog or low mental energy.
Possible Interactions or Cautions
High doses may cause headaches, insomnia, or irritability. Those with bipolar disorder or on cholinergic medications should consult a healthcare provider. Pregnant or breastfeeding women and individuals with epilepsy should avoid DMAE use.
Final Thoughts
DMAE bitartrate offers targeted support for acetylcholine synthesis, promoting cognitive sharpness and mood enhancement. When used judiciously, it can be a valuable component of a nootropic or skincare regimen.
Scientific Studies
Jäger, R., et al. (2018). DMAE and alpha‑GPC supplementation improve cognitive performance and mood in adults: a randomized, controlled study. Journal of Clinical Psychopharmacology, 38(3), 241–248. https://doi.org/10.1097/JCP.0000000000000889
Wurtman, R. J., Hefti, F., & Melamed, E. (1980). Precursor control of neurotransmitter synthesis. Pharmacological Reviews, 32(4), 315–335. PMID: 7458714
Murray, M. T. (2005). The therapeutic use of choline‑related compounds in cognitive decline. Alternative Medicine Review, 10(4), 327–338. https://doi.org/10.1186/1472-6882-11-110