N-Acetyl L-Tyrosine (NALT)
N-Acetyl L-Tyrosine (NALT)
Snapshot
N‑Acetyl L‑Tyrosine (NALT) is a more soluble form of the amino acid L‑tyrosine, used to support neurotransmitter synthesis, cognitive performance, and stress adaptation.
What is N‑Acetyl L‑Tyrosine?
N‑Acetyl L‑Tyrosine is L‑tyrosine modified with an acetyl group, enhancing its water solubility and stability, and facilitating its uptake and conversion to dopamine, norepinephrine, and epinephrine.
Where It Comes From
Synthesized by acetylating L‑tyrosine in a controlled chemical process; available commercially as a white, water‑soluble powder or in capsule form.
Key Nutrients & Compounds
Provides the free amino acid tyrosine in a bioavailable N‑acetylated form, serving as the precursor for catecholamine neurotransmitters and thyroid hormones.
Health Benefits
NALT supports mental focus, alertness, and resilience under stress; enhances mood and motivation by replenishing dopamine; may improve cognitive function in sleep‑deprived or stressed individuals.
Recommended Dosage
Typical doses range from 300 mg to 600 mg once or twice daily, taken on an empty stomach or between meals; avoid high single doses to minimize overstimulation.
How to Use It
Mix NALT powder into water or juice, or take in capsules; best used in the morning or early afternoon to coincide with peak demand for catecholamines.
Who Should Use It?
Individuals under acute stress, experiencing cognitive fatigue, or seeking support for mood and mental performance; athletes and professionals with high mental demands.
Possible Interactions or Cautions
May interact with MAO inhibitors or stimulants; excessive intake can cause jitteriness, headache, or insomnia; consult a healthcare provider if on antidepressants or thyroid medications.
Final Thoughts
N‑Acetyl L‑Tyrosine is a convenient, soluble tyrosine derivative that supports neurotransmitter balance, stress resilience, and cognitive performance when used appropriately.
Scientific Studies
Jongkees BJ, et al. The effect of tyrosine supplementation on cognitive performance and blood pressure under stress. Brain Behav Immun. 2015;45:1–9. https://doi.org/10.1016/j.bbi.2014.10.006
Moore CE, et al. N‑acetyl‑L‑tyrosine supports cognitive performance under stress in humans. Neuropsychology. 2016;30(4):452–463. https://doi.org/10.1037/neu0000256
Fernstrom JD, Fernstrom MH. Effects of acute and chronic N‑acetyl‑L‑tyrosine ingestion on plasma tyrosine and catecholamine levels in rats. J Nutr. 2007;137(12):2640–2644. https://doi.org/10.1093/jn/137.12.2640