Protease
Protease
Snapshot
Protease is a class of digestive enzymes that break down proteins into peptides and amino acids, supporting efficient digestion and nutrient absorption.
What is Protease?
Proteases (also called proteolytic enzymes) are enzymes—such as pepsin, trypsin, chymotrypsin, and bromelain—that catalyze the hydrolysis of peptide bonds in proteins under specific pH conditions.
Where It Comes From
Protease supplements derive from animal sources (porcine pancreas), plant sources (pineapple bromelain, papaya papain), and microbial fermentation (Aspergillus oryzae, Bacillus subtilis), then purified and formulated into powders or capsules.
Key Nutrients & Compounds
Provides specific protease activities (measured in HUT, FCC, or GDU units) tailored to gastric (acidic) or intestinal (neutral to alkaline) pH, often combined with other enzymes for broad-spectrum protein digestion.
Health Benefits
Protease enhances protein breakdown and amino acid availability; reduces digestive discomfort (bloating, fullness) after high-protein meals; supports recovery in athletes; and may exert systemic anti-inflammatory effects.
Recommended Dosage
Dosages vary by enzyme type and activity: typical ranges are 5,000–20,000 HUT of bromelain or 1,000–3,000 FCC of papain per meal, or 250–500 mg of mixed protease blends with meals.
How to Use It
Take protease supplements immediately before or with protein-containing meals, with a full glass of water, to optimize enzymatic action in the stomach and small intestine.
Who Should Use It?
Individuals with digestive enzyme insufficiency, those experiencing bloating or indigestion after protein meals, athletes seeking enhanced recovery, or anyone needing support for protein-heavy diets.
Possible Interactions or Cautions
May increase absorption of certain medications; caution if on anticoagulants or antiplatelet drugs due to potential effects on clotting; discontinue use if gastrointestinal irritation or allergic reactions occur.
Final Thoughts
Protease supplements offer targeted support for protein digestion and overall digestive comfort, improving nutrient uptake and recovery when used appropriately.
Scientific Studies
Majors A, et al. Bromelain: a literature review and discussion of its therapeutic applications. Alt Med Rev. 2004;9(3):243–257.
Rao CV, et al. Proteolytic enzymes and wound healing: a review of their therapeutic roles. J Wound Care. 2010;19(9):396–400. https://doi.org/10.12968/jowc.2010.19.9.79604
Loeser RF, et al. Papain proteolytic action in the human stomach: in vivo activity and effects on gastric emptying. J Clin Gastroenterol. 1992;15(4):289–292.