Red Clover Extract
Red Clover Extract
Snapshot
Red Clover Extract is a standardized botanical supplement rich in isoflavones, used to support menopausal symptoms, bone health, and cardiovascular function.
What is Red Clover Extract?
Red Clover Extract is derived from the aerial parts of Trifolium pratense, standardized to contain 40%–80% isoflavones such as genistein, daidzein, biochanin A, and formononetin.
Where It Comes From
Flowers and leaves are harvested at full bloom, dried, and extracted with ethanol or water–ethanol mixtures, then concentrated and spray‑dried to produce a fine powder.
Key Nutrients & Compounds
Delivers phytoestrogenic isoflavones (genistein, daidzein, biochanin A, formononetin) and flavonoids that modulate estrogen receptor activity and exhibit antioxidant properties.
Health Benefits
Red Clover Extract may alleviate menopausal hot flashes and night sweats; support bone mineral density; improve endothelial function; and provide antioxidant and lipid‑lowering effects.
Recommended Dosage
Standardized extracts (40%–80% isoflavones) are typically dosed at 40–80 mg total isoflavones daily, divided into two doses with meals for optimal absorption.
How to Use It
Take capsules or tablets with water during or after meals; consistent daily use for 8–12 weeks is recommended to assess symptomatic relief.
Who Should Use It?
Women experiencing menopausal symptoms seeking natural relief; individuals interested in support for bone and cardiovascular health; avoid if estrogen‑sensitive conditions exist.
Possible Interactions or Cautions
May interact with hormone‑based therapies and anticoagulants; contraindicated in estrogen‑receptor‑positive cancers; consult a healthcare provider if on prescription medications.
Final Thoughts
Red Clover Extract offers a multi‑faceted isoflavone profile for menopausal support and cardiovascular and bone health, but requires caution in hormone‑sensitive individuals.
Scientific Studies
Albertazzi P, et al. A randomized, controlled trial of red clover isoflavones for the treatment of menopausal hot flushes. Gynecol Endocrinol. 1998;12(3):189–194. https://doi.org/10.3109/09513599808987701
van Dongen MCJM, et al. Effects of Trifolium pratense isoflavones on bone and cardiovascular markers in postmenopausal women: a systematic review. Menopause. 2010;17(6):1172–1181. https://doi.org/10.1097/GME.0b013e3181e4ec9d
Lockwood GA, et al. Isoflavone supplementation in early and late menopause: effects on cardiovascular biomarkers and bone mineral density. J Clin Endocrinol Metab. 2001;86(2):521–526. https://doi.org/10.1210/jcem.86.2.521