Resveratrol
Resveratrol
Snapshot
Resveratrol is a polyphenolic phytoalexin found in grapes, berries, and peanuts, known for its antioxidant, anti‑inflammatory, and cardiovascular protective properties.
What is Resveratrol?
Resveratrol (3,5,4′-trihydroxytrans-stilbene) is a naturally occurring stilbene compound produced by plants in response to stress, exhibiting free‑radical scavenging and cell-signaling modulation.
Where It Comes From
Dietary sources include red grape skins, red wine, blueberries, cranberries, mulberries, and peanuts. Supplemental resveratrol is typically extracted from Japanese knotweed (Polygonum cuspidatum) and standardized to 98% purity.
Key Nutrients & Compounds
Provides trans-resveratrol, the bioactive isomer, which activates sirtuin 1 (SIRT1), modulates NF-κB signaling, and influences mitochondrial function and endothelial nitric oxide synthase (eNOS) activity.
Health Benefits
Resveratrol supports cardiovascular health by improving endothelial function and reducing LDL oxidation; exerts anti‑inflammatory effects by inhibiting pro‑inflammatory cytokines; and may promote healthy aging through SIRT1 activation and mitochondrial biogenesis.
Recommended Dosage
Typical supplemental doses range from 100 mg to 500 mg daily, taken with meals to enhance absorption; doses up to 1 g are used in clinical trials but may increase gastrointestinal discomfort.
How to Use It
Take capsules or powder with a meal containing fat to improve bioavailability; consistent daily intake for at least 4–8 weeks is recommended to observe vascular and metabolic effects.
Who Should Use It?
Individuals seeking antioxidant support, vascular health benefits, or healthy-aging interventions; suitable for adults without contraindications to polyphenol supplementation.
Possible Interactions or Cautions
May interact with anticoagulants (e.g., warfarin) and antiplatelet agents, increasing bleeding risk; high doses can cause gastrointestinal upset; consult a healthcare provider if on prescription medications.
Final Thoughts
Resveratrol is a well‑researched polyphenol offering multifaceted support for cardiovascular, metabolic, and cellular health, though optimal dosing and long‑term safety in high doses require further study.
Scientific Studies
Brasnyó P, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress, and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106(3):383–389. https://doi.org/10.1017/S0007114511000351
Semba RD, et al. Resveratrol concentration and all-cause mortality in older community-dwelling adults. JAMA Intern Med. 2014;174(7):1077–1084. https://doi.org/10.1001/jamainternmed.2014.1668
Wang P, et al. Resveratrol protects against endothelial dysfunction via SIRT1 activation in mice on a high-fat diet. Am J Physiol Heart Circ Physiol. 2012;302(7):H1713–H1722. https://doi.org/10.1152/ajpheart.00552.2011