S-Allyl Cysteine
S-Allyl Cysteine
Snapshot
SโAllyl Cysteine is a waterโsoluble organosulfur compound abundant in aged garlic extract, offering antioxidant, cardioprotective, and neuroprotective benefits through modulation of oxidative stress and inflammation.
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What is SโAllyl Cysteine?
SโAllyl Cysteine (SAC) is a stable, bioavailable sulfurโcontaining amino acid derivative formed during the aging of garlic. Unlike raw garlicโs unstable compounds, SAC survives processing and digestion, making it a key active constituent of aged garlic supplements.
Where It Comes From
SAC is generated when fresh garlic cloves are sliced and macerated in ethanol or water for extended periods (weeks to months). This aging process converts harsher thiosulfinates into gentle, stable compounds. The resulting extract is filtered and concentrated into powders or capsules standardized for SAC content.
Key Nutrients & Compounds
This extract primarily provides Sโallyl cysteine alongside minor amounts of Sโallyl mercaptocysteine, flavonoids, and trace minerals, all contributing synergistically to its bioactivity.
Health Benefits
SโAllyl Cysteine scavenges free radicals and upregulates endogenous antioxidant enzymes, protecting cells from oxidative damage. It supports cardiovascular health by improving endothelial function and reducing blood pressure. Neuroprotective effects include attenuation of neuroinflammation and promotion of neuronal survival.
Recommended Dosage
Typical supplementation involves 100โ300โฏmg of purified SAC per day, often delivered via 600โ1,200โฏmg of aged garlic extract standardized to 2โ5% SAC. Doses may be divided between morning and evening with meals.
How to Use It
Take SACโstandardized aged garlic extract capsules with food to enhance absorption and minimize any mild gastrointestinal discomfort. Maintain consistent daily use for at least 8โ12 weeks to observe cardiovascular or antioxidant benefits.
Who Should Use It?
Individuals seeking natural antioxidant support, those with mild hypertension or cardiovascular risk factors, and anyone wanting gentle garlic benefits without odor or gastric irritation. Consult a healthcare provider when combining with prescription medications.
Possible Interactions or Cautions
Generally well tolerated. Use caution if taking anticoagulant or antiplatelet drugs due to potential additive bloodโthinning effects. Rarely, high doses may cause mild gastrointestinal upset. Discontinue and consult a healthcare professional if adverse reactions occur.
Final Thoughts
SโAllyl Cysteine from aged garlic extract offers a potent, odorโless source of garlicโs therapeutic properties, making it an excellent choice for longโterm cardiovascular and antioxidant support when used responsibly.
Scientific Studies
Yeh YY, Yeh GL. Hypolipidemic and antioxidant effects of aged garlic extract and its constituents, Sโallyl cysteine and Sโallyl mercaptocysteine, in cholesterol-fed rabbits. Nutrition. 2006;22(1):27โ37. https://doi.org/10.1016/j.nut.2005.07.005
Lawson LD, Gardner CD. Composition, stability, and bioavailability of Sโallyl cysteine and Sโallyl mercaptocysteine from aged garlic preparations. Planta Med. 2005;71(9):747โ754. https://doi.org/10.1055/s-2005-872814
Amagase H, Petesch BL, Matsuura H, etย al. Intake of garlic and its bioactive components: Sโallyl cysteine and Sโallyl mercaptocysteine, and association with cardiovascular health. J Nutr. 2001;131(3S):955Sโ962S. https://doi.org/10.1093/jn/131.3.955S